Thursday 29 September 2016

Qinolon




Qinolon may be available in the countries listed below.


Ingredient matches for Qinolon



Ofloxacin

Ofloxacin is reported as an ingredient of Qinolon in the following countries:


  • Philippines

International Drug Name Search

Beparine




Beparine may be available in the countries listed below.


Ingredient matches for Beparine



Heparin

Heparin sodium salt (a derivative of Heparin) is reported as an ingredient of Beparine in the following countries:


  • India

International Drug Name Search

Wednesday 28 September 2016

Chlocodemin




Chlocodemin may be available in the countries listed below.


Ingredient matches for Chlocodemin



Betamethasone

Betamethasone is reported as an ingredient of Chlocodemin in the following countries:


  • Japan

Dexchlorpheniramine

Dexchlorpheniramine maleate (a derivative of Dexchlorpheniramine) is reported as an ingredient of Chlocodemin in the following countries:


  • Japan

International Drug Name Search

Emtryl




Emtryl may be available in the countries listed below.


In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Emtryl



Dimetridazole

Dimetridazole is reported as an ingredient of Emtryl in the following countries:


  • Australia

  • Ireland

  • United Kingdom

International Drug Name Search

Fluocinolone Oil (Body Oil)


Pronunciation: FLOO-oh-SIN-oh-lone
Generic Name: Fluocinolone
Brand Name: Derma-Smoothe/FS Body Oil


Fluocinolone Oil (Body Oil) is used for:

Treating inflammation of the skin. It may also be used for other conditions as determined by your doctor.


Fluocinolone Oil (Body Oil) is a topical corticosteroid. Exactly how it works is unknown.


Do NOT use Fluocinolone Oil (Body Oil) if:


  • you are allergic to any ingredient in Fluocinolone Oil (Body Oil)

Contact your doctor or health care provider right away if any of these apply to you.



Before using Fluocinolone Oil (Body Oil):


Some medical conditions may interact with Fluocinolone Oil (Body Oil). Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you are allergic to peanuts

  • if you have measles, chickenpox, or tuberculosis

  • if you have hardening or thinning of the skin, or a skin infection

  • if you have recently been vaccinated or you have had a positive tuberculin skin test

Some MEDICINES MAY INTERACT with Fluocinolone Oil (Body Oil). Because little, if any, of Fluocinolone Oil (Body Oil) is absorbed into the blood, the risk of it interacting with another medicine is low.


Ask your health care provider if Fluocinolone Oil (Body Oil) may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Fluocinolone Oil (Body Oil):


Use Fluocinolone Oil (Body Oil) as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • For adults: Apply a thin layer of Fluocinolone Oil (Body Oil) to the affected area 3 times a day or as directed by your doctor.

  • For children: Moisten the affected area, and then apply a thin layer of Fluocinolone Oil (Body Oil) twice a day for up to 4 weeks or as directed by your doctor.

  • Wash your hands after applying Fluocinolone Oil (Body Oil), unless your hands are part of the treated area.

  • If you miss a dose of Fluocinolone Oil (Body Oil), use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Fluocinolone Oil (Body Oil).



Important safety information:


  • Fluocinolone Oil (Body Oil) is for external use only. Do not get it in your eyes. If you get Fluocinolone Oil (Body Oil) in your eyes, wash them right away with water.

  • Fluocinolone Oil (Body Oil) contains refined peanut oil. However, Fluocinolone Oil (Body Oil) has not been known to cause an allergic reaction in patients who have a peanut allergy. If you are allergic to peanuts and have questions about using Fluocinolone Oil (Body Oil), check with your doctor.

  • If your condition does not improve within 2 weeks or if it gets worse, contact your doctor.

  • Do not use Fluocinolone Oil (Body Oil) on the face, under the arms, or on the groin unless directed otherwise by your doctor.

  • Fluocinolone Oil (Body Oil) has a corticosteroid in it. Before you start any new medicine, check the label to see if it has a corticosteroid in it too. If it does or if you are not sure, check with your doctor or pharmacist.

  • Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor.

  • Do not use Fluocinolone Oil (Body Oil) for any conditions other than the one for which it was prescribed.

  • Check with your doctor before having vaccinations while using Fluocinolone Oil (Body Oil).

  • Fluocinolone Oil (Body Oil) is not approved to treat diaper rash. Do not apply Fluocinolone Oil (Body Oil) to the diaper area of a child.

  • Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they use Fluocinolone Oil (Body Oil).

  • The body oil should not be used in children younger than 3 months old; safety and effectiveness in these children have not been confirmed.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Fluocinolone Oil (Body Oil) while you are pregnant. It is not known if Fluocinolone Oil (Body Oil) is found in breast milk after topical use. If you are or will be breast-feeding while you use Fluocinolone Oil (Body Oil), check with your doctor. Discuss any possible risks to your baby.


Possible side effects of Fluocinolone Oil (Body Oil):


All medicines may cause side effects, but many people have no, or minor, side effects. No COMMON side effects have been reported with the scalp oil after topical use. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Cough; lightening of the skin; mild fever; nose or throat inflammation; runny nose.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); acne-like rash; inflamed hair follicles; inflammation around the mouth; irritation, burning, redness, or swelling; thinning, softening, or discoloration of the skin.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.



If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include increased thirst or urination; muscle weakness; unusual weight gain, especially in the face.


Proper storage of Fluocinolone Oil (Body Oil):

Store Fluocinolone Oil (Body Oil) at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Fluocinolone Oil (Body Oil) out of the reach of children and away from pets.


General information:


  • If you have any questions about Fluocinolone Oil (Body Oil), please talk with your doctor, pharmacist, or other health care provider.

  • Fluocinolone Oil (Body Oil) is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Fluocinolone Oil (Body Oil). If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Fluocinolone Oil (Body Oil) resources


  • Fluocinolone Oil (Body Oil) Use in Pregnancy & Breastfeeding
  • Fluocinolone Oil (Body Oil) Drug Interactions
  • Fluocinolone Oil (Body Oil) Support Group
  • 3 Reviews for Fluocinolone (Body) - Add your own review/rating


Compare Fluocinolone Oil (Body Oil) with other medications


  • Atopic Dermatitis
  • Dermatitis
  • Lichen Sclerosus

Hydrocortisone Lotion




Dosage Form: lotion
Hydrocortisone Lotion USP, 2.5%

Rx Only



Hydrocortisone Lotion Description


Each mL of Hydrocortisone Lotion USP, 2.5% contains 25 mg of hydrocortisone, USP in a vehicle consisting of carbomer homopolymer type C, ceteareth-20, cetyl alcohol, dehydroacetic acid, DMDM hydantoin, fragrance, glyceryl stearate, isopropyl palmitate, lactic acid, light mineral oil, myristyl alcohol, myristyl lactate, PEG-100 stearate, purified water, sodium hydroxide, sodium PCA, and stearyl alcohol.


Chemically, hydrocortisone is [Pregn-4-ene-3,20-dione, 11, 17, 21-trihydroxy-, (11β)-] with the molecular formula C21H30O5 and is represented by the following structural formula:



Its molecular weight is 362.46 and its CAS Registry Number is 50-23-7. The topical corticosteroids, including hydrocortisone, constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents.



Hydrocortisone Lotion - Clinical Pharmacology


Topical corticosteroids share anti-inflammatory, antipruritic and vasoconstrictive actions. The mechanism of anti-inflammatory activity of the topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.



Pharmacokinetics -


The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings.


Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Thus, occlusive dressings may be a valuable therapeutic adjunct for treatment of resistant dermatoses (see DOSAGE AND ADMINISTRATION).


Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.



Indications and Usage for Hydrocortisone Lotion


Topical corticosteroids are indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.



Contraindications


Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.



Precautions



General -


Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients.


Conditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use, and the addition of occlusive dressings. Therefore, patients receiving a large dose of a potent topical steroid applied to a large surface area or under an occlusive dressing should be evaluated periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests. If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent steroid.


Recovery of HPA axis function is generally prompt and complete upon discontinuation of the drug. Infrequently, signs and symptoms of steroid withdrawal may occur, requiring supplemental systemic corticosteroids.


Children may absorb proportionally larger amounts of topical corticosteroids and thus be more susceptible to systemic toxicity (see PRECAUTIONS: Pediatric Use).


If irritation develops, topical corticosteroids should be discontinued and appropriate therapy instituted.


In the presence of dermatological infections, the use of an appropriate antifungal or antibacterial agent should be instituted. If a favorable response does not occur promptly, the corticosteroid should be discontinued until the infection has been adequately controlled.



Information for the Patient -


Patients using topical corticosteroids should receive the following information and instructions:


1. This medication is to be used as directed by the physician. It is for external use only. Avoid contact with the eyes.


2. Patients should be advised not to use this medication for any disorder other than for which it was prescribed.


3. The treated skin area should not be bandaged or otherwise covered or wrapped as to be occlusive unless directed by the physician.


4. Patients should report any signs of local adverse reactions, especially under occlusive dressings.


5. Parents of pediatric patients should be advised not to use tight-fitting diapers or plastic pants on a child being treated in the diaper area, as these garments may constitute occlusive dressings.



Laboratory Tests -


The following tests may be helpful in evaluating the HPA axis suppression:


Urinary free cortisol test


ACTH stimulation test



Carcinogenesis, Mutagenesis, Impairment of Fertility -


Long-term animal studies have not been performed to evaluate the carcinogenic potential or the effect on fertility of topical corticosteroids.


Studies to determine mutagenicity with prednisolone and hydrocortisone have revealed negative results.



Pregnancy:


Teratogenic Effects:

Pregnancy Category C -


Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels. The more potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. There are no adequate and well-controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids. Therefore, topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Drugs of this class should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time.



Nursing Mothers -


It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk. Systemically administered corticosteroids are secreted into breast milk in quantities not likely to have a deleterious effect on the infant. Nevertheless, caution should be exercised when topical corticosteroids are administered to a nursing woman.



Pediatric Use -


Pediatric patients may demonstrate greater susceptibility to topical corticosteroid-induced HPA axis suppression and Cushing's syndrome than mature patients because of a larger skin surface area to body weight ratio.


Hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing's syndrome, and intracranial hypertension have been reported in pediatric patients receiving topical corticosteroids. Manifestations of adrenal suppression in pediatric patients include linear growth retardation, delayed weight gain, low plasma cortisol levels, and absence of response to ACTH stimulation. Manifestations of intracranial hypertension include bulging fontanelles, headaches, and bilateral papilledema.


Administration of topical corticosteroids to pediatric patients should be limited to the least amount compatible with an effective therapeutic regimen. Chronic corticosteroid therapy may interfere with the growth and development of pediatric patients.



Adverse Reactions


The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence:  burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, and miliaria.



Overdosage


Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects (see PRECAUTIONS).



Hydrocortisone Lotion Dosage and Administration


Shake well before using. Topical corticosteroids are generally applied to the affected area as a thin film from two to four times daily depending on the severity of the condition. Occlusive dressings may be used for the management of psoriasis or recalcitrant conditions.


If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted.



How is Hydrocortisone Lotion Supplied


Hydrocortisone Lotion USP, 2.5% is available as follows:


2 fl oz (59 mL) bottle (NDC 45802-937-16)


4 fl oz (118 mL) bottle (NDC 45802-937-26)



Store at 20-25°C (68-77°F) [see USP Controlled Room Temperature].  Keep tightly closed.  Keep out of the reach of children.



Manufactured by Perrigo


Bronx, NY 10457


Distributed By


Perrigo®


Allegan, MI 49010 • www.perrigo.com


Rev. 01/11


3X100 RC J2



PACKAGE/LABEL PRINCIPAL DISPLAY PANEL


Rx Only


Hydrocortisone Lotion USP, 2.5%


For Topical Use Only


Hydrocortisone Lotion USP, 2.5% Label










HYDROCORTISONE 
hydrocortisone  lotion










Product Information
Product TypeHUMAN PRESCRIPTION DRUGNDC Product Code (Source)45802-937
Route of AdministrationTOPICALDEA Schedule    








Active Ingredient/Active Moiety
Ingredient NameBasis of StrengthStrength
HYDROCORTISONE (HYDROCORTISONE)HYDROCORTISONE25 mg  in 1 mL




































Inactive Ingredients
Ingredient NameStrength
CARBOMER HOMOPOLYMER TYPE C 
POLYOXYL 20 CETOSTEARYL ETHER 
CETYL ALCOHOL 
DEHYDROACETIC ACID 
DMDM HYDANTOIN 
GLYCERYL MONOSTEARATE 
ISOPROPYL PALMITATE 
LACTIC ACID 
LIGHT MINERAL OIL 
MYRISTYL ALCOHOL 
MYRISTYL LACTATE 
PEG-100 STEARATE 
WATER 
SODIUM HYDROXIDE 
SODIUM PYRROLIDONE CARBOXYLATE 
STEARYL ALCOHOL 


















Product Characteristics
Color    Score    
ShapeSize
FlavorImprint Code
Contains      














Packaging
#NDCPackage DescriptionMultilevel Packaging
145802-937-1659 mL In 1 BOTTLENone
245802-937-26118 mL In 1 BOTTLENone










Marketing Information
Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
ANDAANDA08907405/23/2008


Labeler - Perrigo New York Inc (078846912)
Revised: 08/2011Perrigo New York Inc

More Hydrocortisone Lotion resources


  • Hydrocortisone Lotion Use in Pregnancy & Breastfeeding
  • Hydrocortisone Lotion Drug Interactions
  • Hydrocortisone Lotion Support Group
  • 15 Reviews for Hydrocortisone - Add your own review/rating


Compare Hydrocortisone Lotion with other medications


  • Anal Itching
  • Aphthous Stomatitis, Recurrent
  • Atopic Dermatitis
  • Dermatitis
  • Eczema
  • Gingivitis
  • Hemorrhoids
  • Proctitis
  • Pruritus
  • Psoriasis
  • Seborrheic Dermatitis
  • Skin Rash
  • Ulcerative Colitis, Active

Acecor




Acecor may be available in the countries listed below.


Ingredient matches for Acecor



Acebutolol

Acebutolol hydrochloride (a derivative of Acebutolol) is reported as an ingredient of Acecor in the following countries:


  • Czech Republic

  • Poland

  • Slovakia

International Drug Name Search

Esprenit




Esprenit may be available in the countries listed below.


Ingredient matches for Esprenit



Ibuprofen

Ibuprofen is reported as an ingredient of Esprenit in the following countries:


  • Germany

  • Oman

Ibuprofen sodium (a derivative of Ibuprofen) is reported as an ingredient of Esprenit in the following countries:


  • Germany

International Drug Name Search

Betadine Gargle & Mouthwash





1. Name Of The Medicinal Product



Betadine Gargle and Mouthwash.


2. Qualitative And Quantitative Composition



Povidone Iodine USP 1% w/v (equivalent to 0.1% w/v of available iodine).



3. Pharmaceutical Form



Solution.



4. Clinical Particulars



4.1 Therapeutic Indications



For the treatment of acute mucosal infections of the mouth and pharynx, for example gingivitis, and mouth ulcers. For oral hygiene prior to, during and after dental and oral surgery.



4.2 Posology And Method Of Administration



For oral administration, as a gargle and mouthwash. The product should not be swallowed. Adults and children over 6 years of age: Use undiluted or diluted with an equal volume of warm water. Gargle or rinse with up to 10ml for up to 30 seconds without swallowing. Repeat up to four times daily, for up to 14 consecutive days, or as directed.



4.3 Contraindications



Not for use in children under 6 years of age and in patients with a known or suspected iodine hypersensitivity. Regular use is contraindicated in patients and users with thyroid disorders (in particular nodular colloid goitre, endemic goitre and Hashimoto's thyroiditis).



4.4 Special Warnings And Precautions For Use



Regular use should be avoided as prolonged use may lead to the absorption of a significant amount of iodine. Do not use for more than 14 days. If sores or ulcers in the mouth do not heal within 14 days, seek medical or dental advice. Regular use should be avoided in patients on concurrent lithium therapy.



4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction



Absorption of iodine from povidone iodine may interfere with thyroid function tests. Contamination with povidone iodine of several types of tests for the detection of occult blood in faeces or blood in urine may produce false-positive results.



4.6 Pregnancy And Lactation



Regular use of povidone iodine should be avoided in pregnant or lactating women as absorbed iodine can cross the placental barrier and be secreted into breast milk. Although no adverse effects have been reported from limited use, caution should be recommended and therapeutic benefit must be balanced against possible effects of the absorption of iodine on foetal thyroid function and development. The use of Betadine Gargle and Mouthwash in pregnant and lactating women should be limited to a single treatment session only.



4.7 Effects On Ability To Drive And Use Machines



None known.



4.8 Undesirable Effects



Idiosyncratic mucosal irritation and hypersensitivity reactions may occur. Excessive absorption of iodine may produce systemic effects such as metabolic acidosis, hypernatraemia and impairment of renal function.



4.9 Overdose



Excessive iodine can produce goitre and hypothyroidism or hyperthyroidism. Acute overdose may result in symptoms of metallic taste in the mouth, increased salivation, burning or pain in the throat or mouth, irritation and swelling in the eyes, difficulty in breathing due to pulmonary oedema, skin reactions, gastrointestinal upset and diarrhoea. Metabolic acidosis, hypernatraemia and renal impairment may occur. Treatment: In the cases of deliberate or accidental ingestion of large quantities of Betadine, symptomatic and supportive treatment should be provided with special attention to electrolyte balance and renal and thyroid function.



5. Pharmacological Properties



5.1 Pharmacodynamic Properties



Betadine Gargle and Mouthwash contains povidone iodine, a complex of iodine which shows all the broad spectrum germicidal activity of elemental iodine. The germicidal activity is maintained in the presence of blood, pus, serum and necrotic tissue. Betadine Gargle and Mouthwash kills bacteria, viruses, fungi, spores and protozoa.



5.2 Pharmacokinetic Properties



The product is intended for topical application to the mouth and buccal cavity.



5.3 Preclinical Safety Data



None stated.



6. Pharmaceutical Particulars



6.1 List Of Excipients



Glycerol; menthol; methyl salicylate; ethanol 96%; saccharin sodium; purified water.



6.2 Incompatibilities



None stated.



6.3 Shelf Life



36 months unopened.



6.4 Special Precautions For Storage



Store in a dry place below 25oC. Protect from light.



6.5 Nature And Contents Of Container



Amber soda-lime-silica glass bottle (USP Type III) fitted with an externally ribbed white urea cap, with a steran faced wad or with a wadless polypropylene cap containing 250ml of product.



6.6 Special Precautions For Disposal And Other Handling



This product should not be swallowed.



7. Marketing Authorisation Holder



Medlock Medical Limited, Tubiton House, Oldham, OL1 3HS.



8. Marketing Authorisation Number(S)



PL 21248/0006.



9. Date Of First Authorisation/Renewal Of The Authorisation



30th September 2005.



10. Date Of Revision Of The Text



September 2005.




Eurorapi




Eurorapi may be available in the countries listed below.


Ingredient matches for Eurorapi



Rabeprazole

Rabeprazole is reported as an ingredient of Eurorapi in the following countries:


  • Vietnam

International Drug Name Search

Esat




Esat may be available in the countries listed below.


Ingredient matches for Esat



Risedronic Acid

Risedronic Acid monosodium (a derivative of Risedronic Acid) is reported as an ingredient of Esat in the following countries:


  • Dominican Republic

International Drug Name Search

Tuesday 27 September 2016

Espasevit




Espasevit may be available in the countries listed below.


Ingredient matches for Espasevit



Ondansetron

Ondansetron is reported as an ingredient of Espasevit in the following countries:


  • Peru

Ondansetron hydrochloride (a derivative of Ondansetron) is reported as an ingredient of Espasevit in the following countries:


  • Argentina

International Drug Name Search

Poen Efrina




Poen Efrina may be available in the countries listed below.


Ingredient matches for Poen Efrina



Phenylephrine

Phenylephrine hydrochloride (a derivative of Phenylephrine) is reported as an ingredient of Poen Efrina in the following countries:


  • Argentina

International Drug Name Search

AdreView


Generic Name: iobenguane i 123 (Intravenous route)


eye-oh-BEN-gwane I 123


Commonly used brand name(s)

In the U.S.


  • AdreView

Available Dosage Forms:


  • Solution

Therapeutic Class: Diagnostic Agent, Radiopharmaceutical Imaging


Uses For AdreView


Iobenguane I 123 is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents, which may be used to find and treat certain diseases or to study the function of the body's organs.


Iobenguane I 123 is used to find certain kinds of cancer of the adrenal glands.


When very small doses of iobenguane I 123 are given, the radioactivity taken up by the adrenal gland helps find tumors of the adrenal glands. An image of the gland on film or on a computer screen can be provided to help with the diagnosis.


Iobenguane I 123 is to be given only by or under the direct supervision of a doctor with specialized training in nuclear medicine.


Before Using AdreView


In deciding to use a diagnostic test, any risks of the test must be weighed against the good it will do. This is a decision you and your doctor will make. Also, other things may affect test results. For this test, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Appropriate studies have not been performed on the relationship of age to the effects of iobenguane I 123 in infants below 1 month of age. Safety and efficacy have not been established.


Geriatric


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of iobenguane I 123 in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require an adjustment in the dose for patients receiving iobenguane I 123.


Pregnancy








Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding


Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.


Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


Other Medical Problems


The presence of other medical problems may affect the use of this diagnostic test. Make sure you tell your doctor if you have any other medical problems, especially:


  • Hypertension (high blood pressure) or

  • Thyroid problems—Use with caution. May make these conditions worse.

  • Kidney disease, severe—Use with caution. The effects of this medicine may be increased because of slower removal from the body.

Proper Use of AdreView


Your doctor or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins.


Precautions While Using AdreView


It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly.


This medicine contains benzyl alcohol which may cause serious reactions to premature or low-birthweight infants. Discuss this with your doctor if you are concerned.


Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.


AdreView Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor or nurse immediately if any of the following side effects occur:


Incidence not known
  • Difficulty in breathing and/or swallowing

  • fever

  • hives

  • nausea

  • reddening of the skin, especially around ears swelling of eyes, face, or inside of nose

  • unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


Less common
  • Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at site

  • dizziness

  • feeling of warmth or redness of the face, neck, arms and occasionally, upper chest

  • skin rash or itching

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: AdreView side effects (in more detail)



The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.


The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.


More AdreView resources


  • AdreView Side Effects (in more detail)
  • AdreView Drug Interactions
  • AdreView Support Group
  • 0 Reviews for AdreView - Add your own review/rating


  • AdreView Prescribing Information (FDA)

  • AdreView Consumer Overview



Compare AdreView with other medications


  • Diagnosis and Investigation

Catapres-TTS-1 Transdermal


Generic Name: clonidine (Transdermal route)

KLOE-ni-deen

Commonly used brand name(s)

In the U.S.


  • Catapres-TTS-1

  • Catapres-TTS-2

  • Catapres-TTS-3

Available Dosage Forms:


  • Patch, Extended Release

Therapeutic Class: Antihypertensive


Pharmacologic Class: Alpha-2 Adrenergic Agonist


Uses For Catapres-TTS-1


Clonidine transdermal is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk for heart attacks. These problems may be less likely to occur if the blood pressure is controlled.


Clonidine belongs to the class of medicines called antihypertensives. It works in the brain to change some of the nerve impulses. As a result, the blood vessels relax and blood passes through them more easily, which lowers blood pressure. When the blood pressure is lowered, the amount of blood and oxygen going to the heart is increased.


This medicine will not cure your high blood pressure, but it does help control it. Therefore, you must continue to use it as directed if you expect to lower your blood pressure and keep it down. You might have to take high blood pressure medicine for the rest of your life.


This medicine is available only with your doctor's prescription.


Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, clonidine transdermal is used in certain patients with the following medical conditions:


  • Menopause or menstrual discomfort symptoms.

  • Withdrawal symptoms from nicotine.

Before Using Catapres-TTS-1


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Appropriate studies have not been performed on the relationship of age to the effects of clonidine transdermal in the pediatric population. Safety and efficacy have not been established.


Geriatric


No information is available on the relationship of age to the effects of clonidine transdermal in geriatric patients. However, elderly patients are more likely to have age-related heart or kidney problems, which may require caution and an adjustment in the dose for patients receiving clonidine transdermal.


Pregnancy








Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding


Studies suggest that this medication may alter milk production or composition. If an alternative to this medication is not prescribed, you should monitor the infant for side effects and adequate milk intake.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Acebutolol

  • Amitriptyline

  • Amoxapine

  • Atenolol

  • Betaxolol

  • Bevantolol

  • Bisoprolol

  • Carteolol

  • Celiprolol

  • Clomipramine

  • Desipramine

  • Dilevalol

  • Diltiazem

  • Dothiepin

  • Doxepin

  • Esmolol

  • Imipramine

  • Levobunolol

  • Lofepramine

  • Metipranolol

  • Metoprolol

  • Mirtazapine

  • Nadolol

  • Nebivolol

  • Nortriptyline

  • Oxprenolol

  • Penbutolol

  • Pindolol

  • Propranolol

  • Protriptyline

  • Sotalol

  • Tertatolol

  • Timolol

  • Trimipramine

  • Verapamil

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Cyclosporine

  • Fluphenazine

  • Mepivacaine

  • Naloxone

  • Yohimbine

Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


Other Medical Problems


The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:


  • Heart attack, recent or

  • Heart or blood vessel disease or

  • Heart rhythm problems or

  • Stroke—Use with caution. May cause side effects to become worse.

  • Irritated or scraped skin—Effects may be increased because more medicine is absorbed in the body.

  • Kidney disease—Effects may be increased because of slower removal from the body.

Proper Use of clonidine

This section provides information on the proper use of a number of products that contain clonidine. It may not be specific to Catapres-TTS-1. Please read with care.


Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.


In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.


Many patients who have high blood pressure will not notice any signs of the problem. In fact, many patients feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.


Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.


To use the skin patch:


  • Use this medicine exactly as directed by your doctor. It will work only if applied correctly. This medicine usually comes with patient instructions. Read them carefully before applying the patch.

  • Wash your hands with soap and water before and after applying a patch. Do not touch your eyes until after you have washed your hands.

  • Do not try to trim or cut the adhesive patch to adjust the dosage. Check with your doctor if you think the medicine is not working as it should.

  • Gently wash the area of skin where you will apply the patch with soap and water. Rinse the skin completely and dry with a clean, dry tissue.

  • Apply the patch right away after removing it from the pouch. Do not cut it into smaller pieces and do not touch the sticky surface of the patch.

  • Apply the patch to a clean, dry, and intact skin area on your upper, outer arm or upper chest. Choose an area with little or no hair that is free of scars, cuts, or irritation. Avoid putting the patch on skin areas where it could be rubbed off by tight clothing.

  • Press the patch firmly in place with your fingertips to make sure that the edges stick well.

  • The patch should stay in place during showering, bathing, or swimming for a full 7 days. If the patch becomes loose, press the edges against the skin and cover the patch with one of the white adhesive covers that are included in the package. Apply a new patch if the first one becomes too loose or falls off.

  • It is best to apply each patch to a different area of the skin to prevent skin irritation.

To help you remember to use your medicine, try to apply the patch at the same time and on the same day of the week.


Dosing


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • For transdermal dosage form (patch):
    • For high blood pressure:
      • Adults—One patch applied once every 7 days. Your doctor may adjust your dose as needed.

      • Children—Use and dose must be determined by your doctor.



Missed Dose


If you forget to wear or change a patch, put one on as soon as you can. If it is almost time to put on your next patch, wait until then to apply a new patch and skip the one you missed. Do not apply extra patches to make up for a missed dose.


If you miss changing the transdermal patch for 2 or more days, check with your doctor right away. If your body goes without this medicine for too long, your blood pressure may go up to a very high level and cause serious side effects.


Storage


Store the patches at room temperature in a closed container, away from heat, moisture, and direct light.


Keep out of the reach of children.


Do not keep outdated medicine or medicine no longer needed.


Ask your healthcare professional how you should dispose of any medicine you do not use.


After removing a used patch, fold the patch in half with the sticky sides together. Make sure to dispose of it out of the reach of children and pets.


Precautions While Using Catapres-TTS-1


It is important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for any unwanted effects.


Do not interrupt or stop using this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. Your blood pressure may become worse when the medicine is stopped suddenly, which can cause serious side effects.


Make sure that you have enough clonidine transdermal on hand to last through weekends, holidays, or vacations. You should not miss any doses. You may want to ask your doctor for a second written prescription for clonidine to carry in your wallet or purse. You can have it filled if you run out of medicine when you are away from home.


You may have some skin redness, a rash, itching, or blistering at the place where you wear the patch. If this irritation is severe or does not go away, call your doctor. Do not remove the patch unless your doctor tells you to.


Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are using this medicine.


Before having a magnetic resonance imaging (MRI) scan, tell the doctor in charge that you are using this medicine. Skin burns may occur at the site where the patch is worn during this procedure. Ask your doctor if the patch should be removed before having an MRI scan. You might need to put on a new patch after the procedure.


Clonidine transdermal may cause some people to become drowsy or less alert than they are normally. This is more likely to happen when you begin to use it or when you increase the amount of medicine you are using. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert.


Clonidine transdermal will add to the effects of alcohol and other central nervous system (CNS) depressants. CNS depressants are medicines that slow down the nervous system and may cause drowsiness. Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates or medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.


This medicine may cause dryness of the eyes. If you wear contact lenses, this may be a problem for you. Talk to your doctor if you wear contact lenses, and discuss how to treat the dryness.


Dizziness, lightheadedness, or fainting may occur after you use this medicine, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help, but if the problem continues or gets worse, check with your doctor.


The dizziness, lightheadedness, or fainting is also more likely to occur if you drink alcohol, stand for long periods of time, exercise, or if the weather is hot. While you are using clonidine, be careful to limit the amount of alcohol you drink. Also, use extra care during exercise or hot weather or if you must stand for a long time.


Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. You should avoid over-the-counter [OTC] medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may tend to increase your blood pressure.


Catapres-TTS-1 Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor immediately if any of the following side effects occur:


More common
  • Itching or redness of the skin

Incidence not known
  • Blistering, burning, crusting, dryness, or flaking of the skin

  • blurred vision

  • chest pain or discomfort

  • darkening of the skin

  • decreased urine output

  • dilated neck veins

  • dizziness

  • extreme fatigue

  • fainting

  • fast, slow, pounding, or irregular heartbeat or pulse

  • fever

  • general feeling of discomfort or illness

  • inability to speak

  • irregular breathing

  • itching, scaling, severe redness, soreness, or swelling of the skin

  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

  • lightheadedness, dizziness, or fainting

  • paleness or cold feeling in the fingertips and toes

  • seizures

  • severe or sudden headache

  • shortness of breath

  • slurred speech

  • swelling of the face, fingers, feet, or lower legs

  • temporary blindness

  • tightness in the chest

  • tingling or pain in the fingers or toes when exposed to cold

  • troubled breathing

  • unusual tiredness or weakness

  • weakness in the arm or leg on one side of the body, sudden and severe

  • weight gain

  • wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:


Symptoms of overdose
  • Bluish lips or skin

  • change in consciousness

  • clumsiness

  • confusion

  • constricted, pinpoint, or small pupils (black part of the eye)

  • depression

  • difficult or troubled breathing

  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

  • drowsiness

  • headache

  • irregular, fast or slow, or shallow breathing

  • irritability

  • lack of coordination

  • loss of consciousness

  • low body temperature

  • muscle aches or weakness

  • nervousness

  • not breathing

  • pale or blue lips, fingernails, or skin

  • pounding in the ears

  • shivering

  • sleepiness

  • sweating

  • weak or feeble pulse

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


Incidence not known
  • Anxiety

  • burning or dryness of the eyes

  • confusion as to time, place, or person

  • decreased interest in sexual intercourse

  • dry mouth

  • hair loss

  • hives or welts

  • holding false beliefs that cannot be changed by fact

  • hyperventilation

  • inability to have or keep an erection

  • itching skin

  • leg cramps

  • loss in sexual ability, desire, drive, or performance

  • loss of appetite

  • muscle or joint pain

  • raised red swellings on the skin, lips, tongue, or in the throat

  • redness of the skin

  • restlessness

  • seeing, hearing, or feeling things that are not there

  • shaking

  • skin rash

  • swelling of the breasts or breast soreness in both females and males

  • thinning of the hair

  • trouble sleeping

  • unusual excitement, nervousness, or restlessness

  • vivid dreams or nightmares

  • weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Catapres-TTS-1 Transdermal side effects (in more detail)



The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.


The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.


More Catapres-TTS-1 Transdermal resources


  • Catapres-TTS-1 Transdermal Side Effects (in more detail)
  • Catapres-TTS-1 Transdermal Use in Pregnancy & Breastfeeding
  • Drug Images
  • Catapres-TTS-1 Transdermal Drug Interactions
  • Catapres-TTS-1 Transdermal Support Group
  • 4 Reviews for Catapres-TTS-1 Transdermal - Add your own review/rating


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  • Perimenopausal Symptoms
  • Smoking Cessation

Espasmosedil




Espasmosedil may be available in the countries listed below.


Ingredient matches for Espasmosedil



Clonixin

Clonixin lysine salt (a derivative of Clonixin) is reported as an ingredient of Espasmosedil in the following countries:


  • Peru

Pargeverine

Pargeverine hydrochloride (a derivative of Pargeverine) is reported as an ingredient of Espasmosedil in the following countries:


  • Peru

International Drug Name Search

Enalapril Adico




Enalapril Adico may be available in the countries listed below.


Ingredient matches for Enalapril Adico



Enalapril

Enalapril maleate (a derivative of Enalapril) is reported as an ingredient of Enalapril Adico in the following countries:


  • Switzerland

International Drug Name Search

Monday 26 September 2016

PZA




PZA may be available in the countries listed below.


Ingredient matches for PZA



Pyrazinamide

Pyrazinamide is reported as an ingredient of PZA in the following countries:


  • Peru

International Drug Name Search

trihexyphenidyl


Generic Name: trihexyphenidyl (try hex ee FEH nih dill)

Brand Names: Artane, Trihexane


What is trihexyphenidyl?

Trihexyphenidyl alters unusual nerve impulses and relaxes stiff muscles.


Trihexyphenidyl is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease. It is also used to treat and prevent the same muscular conditions when they are caused by drugs such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), haloperidol (Haldol), thiothixene (Navane), and others.


Trihexyphenidyl may also be used for purposes other than those listed in this medication guide.


What is the most important information I should know about trihexyphenidyl?


Use caution when driving, operating machinery, or performing other hazardous activities. Trihexyphenidyl may cause dizziness or blurred vision. If you experience dizziness or blurred vision, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking trihexyphenidyl.

Avoid becoming overheated. Trihexyphenidyl may cause decreased sweating. This could lead to heat stroke in hot weather or with vigorous exercise.


What should I discuss with my healthcare provider before taking trihexyphenidyl?


Do not use trihexyphenidyl without first talking to your doctor if you have

  • ever had an allergic reaction to it;




  • narrow-angle glaucoma;




  • an obstruction in the bowel or a complication of bowel disease known as megacolon; or




  • myasthenia gravis.



Before taking this medication, tell your doctor if you have



  • enlargement of the prostate or difficulty urinating;




  • epilepsy or another seizure disorder;




  • heart disease or an irregular heartbeat;




  • depression or any other psychiatric illness;



  • kidney disease; or

  • liver disease.

You may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.


It is not known whether trihexyphenidyl will be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether trihexyphenidyl passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take trihexyphenidyl?


Take trihexyphenidyl exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.


Take each dose with a full glass of water. Trihexyphenidyl may be taken with or without meals. Taking trihexyphenidyl with food may lessen stomach upset.

To ensure that you get a correct dose, measure the liquid form of trihexyphenidyl with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.


Store trihexyphenidyl at room temperature away from moisture and heat.

See also: Trihexyphenidyl dosage (in more detail)

What happens if I miss a dose?


Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and only take the next regularly scheduled dose. Do not take a double dose of this medication.


What happens if I overdose?


Seek emergency medical attention.

Symptoms of a trihexyphenidyl overdose include large pupils; warm, dry skin; flushed face; fever; dry mouth; fast or irregular heartbeat; anxiety; hallucinations; confusion; agitation; hyperactivity; loss of consciousness; and seizures.


What should I avoid while taking trihexyphenidyl?


Use caution when driving, operating machinery, or performing other hazardous activities. Trihexyphenidyl may cause dizziness or blurred vision. If you experience dizziness or blurred vision, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking trihexyphenidyl.

Avoid becoming overheated. Trihexyphenidyl may cause decreased sweating. This could lead to heat stroke in hot weather or with vigorous exercise. Try to keep as cool as possible and watch for signs of heat stroke such as decreased sweating, nausea, and dizziness.


Trihexyphenidyl side effects


If you experience any of the following serious side effects, stop taking trihexyphenidyl and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);




  • fever;




  • fast or irregular heartbeats;




  • anxiety, hallucinations, confusion, agitation, hyperactivity, or loss of consciousness;




  • seizures;




  • eye pain; or




  • a rash.



Other, less serious side effects may be more likely to occur. Continue to take trihexyphenidyl and talk to your doctor if you experience



  • dryness of the mouth;




  • large pupils or blurred vision;




  • drowsiness or dizziness;




  • difficulty urinating or constipation;




  • nervousness or anxiety;




  • upset stomach; or




  • decreased sweating.



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Trihexyphenidyl Dosing Information


Usual Adult Dose for Extrapyramidal Reaction:

4 to 10 mg orally each day. The total daily dose is best tolerated when administered in 2 or three equally separated doses.

Usual Adult Dose for Parkinson's Disease:

Initial: 1 mg/day; increase by 2 mg increments at intervals of 3 to 5 days
Usual dose: 6 to 10 mg/day in 3 to 4 divided doses; doses of 12 to 15 mg/day may be required

Drug-induced extrapyramidal symptoms: Initial: 1 mg/day; increase as necessary to usual range of 5 to 15 mg/day in 3 to 4 divided doses

Use in combination with levodopa: Usual range: 3 to 6 mg/day in divided doses

Usual Pediatric Dose for Cerebral Spasticity:

Oral:
Children 2 to 17 years old:
Dystonia in cerebral palsy:
Initial: 0.1 to 0.2 mg/kg/day in three divided doses for 1 week; increase by 0.05 to 0.3 mg/kg/day in three divided doses for the second week; thereafter, titrate up weekly by 0.05 to 0.5 mg/kg/day in three divided doses as clinically tolerated
Maximum dose: 0.75 mg/kg/day


What other drugs will affect trihexyphenidyl?


Before taking this medication, tell your doctor if you are taking any of the following medicines:


  • a tricyclic antidepressant (used to treat depression, pain, or obsessive-compulsive disorder) such as amitriptyline (Elavil, Endep), doxepin (Sinequan), clomipramine (Anafranil), amoxapine (Asendin), desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), or protriptyline (Vivactil);


  • a phenothiazine (used to treat mania, schizophrenia, other psychiatric conditions, and nausea and vomiting) such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), mesoridazine (Serentil), thioridazine (Mellaril), promazine (Sparine), trifluoperazine (Stelazine), and others;




  • thiothixene (Navane) or chlorprothixene (Taractan);




  • an antihistamine such as diphenhydramine (Benadryl, others), chlorpheniramine (Chlor-Trimeton, others), triprolidine (Actifed, others), brompheniramine (Dimetapp, others), clemastine (Tavist), and others (antihistamines are often found in prescription and over-the-counter cold, allergy, and sleep medicines);




  • quinidine (Quinora, Quinaglute, Quinidex, Cardioquin);




  • amantadine (Symmetrel);




  • digoxin (Lanoxin, Lanoxicaps); or




  • haloperidol (Haldol).



You may not be able to take trihexyphenidyl or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.


Drugs other than those listed here may also interact with trihexyphenidyl. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.



More trihexyphenidyl resources


  • Trihexyphenidyl Side Effects (in more detail)
  • Trihexyphenidyl Dosage
  • Trihexyphenidyl Use in Pregnancy & Breastfeeding
  • Drug Images
  • Trihexyphenidyl Drug Interactions
  • Trihexyphenidyl Support Group
  • 4 Reviews for Trihexyphenidyl - Add your own review/rating


  • trihexyphenidyl Advanced Consumer (Micromedex) - Includes Dosage Information

  • Trihexyphenidyl MedFacts Consumer Leaflet (Wolters Kluwer)

  • Trihexyphenidyl Prescribing Information (FDA)

  • Trihexyphenidyl Hydrochloride Monograph (AHFS DI)



Compare trihexyphenidyl with other medications


  • Cerebral Spasticity
  • Extrapyramidal Reaction
  • Parkinson's Disease


Where can I get more information?


  • Your pharmacist has more information about trihexyphenidyl written for health professionals that you may read.

See also: trihexyphenidyl side effects (in more detail)


EnaHexal




EnaHexal may be available in the countries listed below.


Ingredient matches for EnaHexal



Enalapril

Enalapril is reported as an ingredient of EnaHexal in the following countries:


  • Vietnam

Enalapril maleate (a derivative of Enalapril) is reported as an ingredient of EnaHexal in the following countries:


  • Australia

  • Bulgaria

  • Estonia

  • Georgia

  • Germany

  • Latvia

  • Lithuania

  • Romania

  • Serbia

International Drug Name Search

Etoposide Crinos




Etoposide Crinos may be available in the countries listed below.


Ingredient matches for Etoposide Crinos



Etoposide

Etoposide is reported as an ingredient of Etoposide Crinos in the following countries:


  • Italy

International Drug Name Search

Enalapril Arrow




Enalapril Arrow may be available in the countries listed below.


Ingredient matches for Enalapril Arrow



Enalapril

Enalapril maleate (a derivative of Enalapril) is reported as an ingredient of Enalapril Arrow in the following countries:


  • France

International Drug Name Search

Ketamav




Ketamav may be available in the countries listed below.


In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Ketamav



Ketamine

Ketamine hydrochloride (a derivative of Ketamine) is reported as an ingredient of Ketamav in the following countries:


  • Australia

International Drug Name Search

Etoposid Sandoz




Etoposid Sandoz may be available in the countries listed below.


Ingredient matches for Etoposid Sandoz



Etoposide

Etoposide is reported as an ingredient of Etoposid Sandoz in the following countries:


  • Germany

International Drug Name Search

Polymyxine B




Polymyxine B may be available in the countries listed below.


Ingredient matches for Polymyxine B



Polymyxin B

Polymyxine B (DCF) is known as Polymyxin B in the US.

International Drug Name Search

Glossary

DCFDénomination Commune Française

Click for further information on drug naming conventions and International Nonproprietary Names.

Bonalfa High




Bonalfa High may be available in the countries listed below.


Ingredient matches for Bonalfa High



Tacalcitol

Tacalcitol is reported as an ingredient of Bonalfa High in the following countries:


  • Japan

International Drug Name Search

Friday 23 September 2016

Meipril




Meipril may be available in the countries listed below.


Ingredient matches for Meipril



Enalapril

Enalapril maleate (a derivative of Enalapril) is reported as an ingredient of Meipril in the following countries:


  • Indonesia

International Drug Name Search

Easyhaler Beclometasone




Easyhaler Beclometasone may be available in the countries listed below.


UK matches:

  • Easyhaler Beclometasone 200 micrograms/dose inhalation powder (SPC)

Ingredient matches for Easyhaler Beclometasone



Beclometasone

Beclometasone 17α,21-dipropionate (a derivative of Beclometasone) is reported as an ingredient of Easyhaler Beclometasone in the following countries:


  • United Kingdom

International Drug Name Search

Glossary

SPC Summary of Product Characteristics (UK)

Click for further information on drug naming conventions and International Nonproprietary Names.

Espram




Espram may be available in the countries listed below.


Ingredient matches for Espram



Esomeprazole

Esomeprazole is reported as an ingredient of Espram in the following countries:


  • Bangladesh

International Drug Name Search

Propil




Propil may be available in the countries listed below.


Ingredient matches for Propil



Propylthiouracil

Propylthiouracil is reported as an ingredient of Propil in the following countries:


  • Brazil

International Drug Name Search

Epirubicin Medicopharm




Epirubicin Medicopharm may be available in the countries listed below.


Ingredient matches for Epirubicin Medicopharm



Epirubicin

Epirubicin hydrochloride (a derivative of Epirubicin) is reported as an ingredient of Epirubicin Medicopharm in the following countries:


  • Germany

International Drug Name Search

Exuna




Exuna may be available in the countries listed below.


Ingredient matches for Exuna



Algestone Acetophenide

Algestone Acetophenide is reported as an ingredient of Exuna in the following countries:


  • Peru

Estradiol

Estradiol 17ß-enantate (a derivative of Estradiol) is reported as an ingredient of Exuna in the following countries:


  • Peru

International Drug Name Search

Esotid




Esotid may be available in the countries listed below.


Ingredient matches for Esotid



Esomeprazole

Esomeprazole is reported as an ingredient of Esotid in the following countries:


  • Bangladesh

International Drug Name Search